Mentors at Your Benchside

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A Short History of Cryo-Electron Microscopy

Updated about 1 month ago.

#3 — In this episode of Mentors At Your Benchside, listen to a short history of cryo-electron microscopy—the Nobel Prize-winning technique revolutionizing molecular and structural biology.

The journey takes us from the inception of cryo-EM- obscure, inferior, and derided- to the present-day competition for access to the incredibly powerful Krios microscopes.

It's all about the power of an image.

And speaking of images, be sure to read A Short History of Cryo-Electron Microscopy for a graphical timeline and some stunning cryo-EM structures. [1]

Fascinating, cross-disciplinary science underpins cryo-EM—the technique is as broad as it is popular. To expand your understanding of the fundamental science behind it, Read What Is Cryo-Electron Microscopy? A Brief Introduction. [2] For tips and tricks on getting your sample ready for a cryo-EM experiment, check out Cryo-EM Sample Prep: 5 Crucial Considerations. [3] And for a simple illustration of the stunning structures cryo-EM produces, browse the Electron Microscopy Data Bank. [4]

Resources:
1. A Short History of Cryo-Electron Microscopy. Available at: https://bitesizebio.com/62839/history-of-cryo-electron-microscopy/
2. What Is Cryo-Electron Microscopy? A Brief Introduction. Available at: https://bitesizebio.com/62871/what-is-cryo-electron-microscopy/
3. Cryo-EM Sample Prep: 5 Crucial Considerations. Available at: https://bitesizebio.com/62619/cryo-em-sample-prep/
4. Electron Microscopy Data Bank. Available at: https://www.ebi.ac.uk/emdb/

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